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Article

Effect of Disease-Associated P123H and V70M Mutations on β-Synuclein Fibrillation.

ACS chemical neuroscience - 16 Sept 2020

Sharma Karan, Mehra Surabhi, Sawner Ajay S, Markam Pratap S, Panigrahi Rajlaxmi, Navalkar Ambuja, Chatterjee Debdeep, Kumar Rakesh, Kadu Pradeep, Patel Komal, Ray Soumik, Kumar Ashutosh, Maji Samir K

Abstract excerpt

Synucleinopathies are a class of neurodegenerative diseases, including Parkinson's disease (PD), Dementia with Lewy bodies (DLB), and Multiple System Atrophy (MSA). The common pathological hallmark of synucleinopathies is the filamentous α-synuclein (α-Syn) aggregates along with membrane components in cytoplasmic inclusions in the brain. β-Synuclein (β-Syn), an isoform of α-Syn, inhibits α-Syn aggregation and...

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PMID: 32833434
DOI: 10.1021/acschemneuro.0c00405

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