Article

Platelet phosphatidylserine is the critical mediator of thrombosis in heparin-induced thrombocytopenia

2022-09-15

Abstract excerpt

Heparin-induced thrombocytopenia (HIT) is a severe immune-mediated prothrombotic disorder caused by antibodies reactive to complexes of platelet factor 4 and heparin. Platelets (PLTs) and their interaction with different immune cells contribute to prothrombotic conditions in HIT. However, the exact mechanisms and the role of different PLT subpopulations to this prothrombotic enviroment remain poorly understood. In...

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Literature Corpus work: 156b6ab4-7fe1-5490-b7e0-e8034d744d07
DOI: 10.1101/2022.09.13.507721

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