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Article

Nucleolar dynamics are determined by the ordered assembly of the ribosome.

The Journal of cell biology - 2 Nov 2026

Sheu-Gruttadauria Jessica, Yan Xiaowei, Stuurman Nico, Ogrean Riley O, Lin Sabrina, Floor Stephen N, Vale Ronald D

Abstract excerpt

Ribosome biogenesis occurs in the nucleolus, a biomolecular condensate whose material properties are thought to be important for function. However, the molecular basis of nucleolar dynamics and their relationship to ribosome assembly remain incompletely understood. We present a platform for high-throughput FRAP (HiT-FRAP) and use it to screen hundreds of genes for their impact on dynamics of the nucleolar...

Read the complete abstract on PubMed

Topics

Nucleophosmin
Cell Nucleolus
Ribosomes
Nuclear Proteins
Humans
Fluorescence Recovery After Photobleaching

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Mutation

Source

Identifiers

PMID: 42714337
DOI: 10.1083/jcb.202605096

Genes

NPM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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