Article
In Vitro Evaluation of the Reductase Activities of Human AKR1C3 Allelic Variants.
Drug metabolism and disposition: the biological fate of chemicals - 1 Sept 2023
Takano Shiori, Fukami Tatsuki, Ichida Hiroyuki, Suzuki Kohei, Nakano Masataka, Nakajima Miki
Abstract excerpt
Aldo-keto reductase 1C3 (AKR1C3) plays a role in the detoxification and activation of clinical drugs by catalyzing reduction reactions. There are approximately 400 single-nucleotide polymorphisms (SNPs) in the AKR1C3 gene, but their impact on the enzyme activity is still unclear. This study aimed to clarify the effects of SNPs of AKR1C3 with more than 0.5% global minor allele frequency on the reductase activities...
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