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Article

Naturally occurring variants of human CBR3 alter anthracycline in vitro metabolism.

The Journal of pharmacology and experimental therapeutics - 1 Mar 2010

Bains Onkar S, Karkling Morgan J, Lubieniecka Joanna M, Grigliatti Thomas A, Reid Ronald E, Riggs K Wayne

Abstract excerpt

Doxorubicin (DOX) and daunorubicin (DAUN) are anthracycline anticancer agents; however, considerable interpatient variability exists in their pharmacokinetics. This interpatient variability is attributed in part to altered metabolism by nonsynonymous single-nucleotide polymorphisms (ns-SNPs) in genes encoding the carbonyl reductases. This study examines the effect of seven naturally occurring ns-SNPs in the CBR3...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 20007405
DOI: 10.1124/jpet.109.160614

Genes

CBR3

Variants

Provenance

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