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Article

Instability of C154Y variant of aldo-keto reductase 1C3.

Chemico-biological interactions - 1 Oct 2017

Endo Satoshi, Takada Sayaka, Honda Ryo P, Müller Kathrin, Weishaupt Jochen H, Andersen Peter M, Ludolph Albert C, Kamatari Yuji O, Matsunaga Toshiyuki, Kuwata Kazuo, El-Kabbani Ossama, Ikari Akira

Abstract excerpt

Aldo-keto reductase (AKR) 1C3 is a cytosolic enzyme that metabolizes steroids, prostaglandins, toxic aldehydes and drugs. Recently, some nonsynonymous single nucleotide polymorphisms of AKR1C3 have been suggested to impact steroid and drug metabolism. In this study, we examined the effects of C154Y and L159V variants of AKR1C3 on stability and function of the enzyme. Both variants had been detected in patients...

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PMID: 28025170
DOI: 10.1016/j.cbi.2016.12.018

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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