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Article

Correlation of aldo-ketoreductase (AKR) 1C3 genetic variant with doxorubicin pharmacodynamics in Asian breast cancer patients.

British journal of clinical pharmacology - 1 Jun 2013

Voon Pei Jye, Yap Hui Ling, Ma Cho-Yee-Thu, Lu Fan, Wong Andrea L A, Sapari Nur Sabrina, Soong Richie, Soh Thomas I P, Goh Boon-Cher, Lee How-Sung, Lee Soo-Chin

Abstract excerpt

AIMS: Aldo-ketoreductases have been implicated in the metabolism of doxorubicin. We sought to assess the influence of AKR1C3 genetic variants on doxorubicin metabolism. METHODS: We sequenced AKR1C3 exon 5 and genotyped seven functional single nucleotide polymorphisms in CBR3, ABCB1 and SLC22A16 involved in doxorubicin pharmacology in 151 Asian breast cancer patients treated with doxorubicin-containing...

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Share to 3-Hydroxysteroid Dehydrogenases
Share to Alcohol Oxidoreductases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Antibiotics, Antineoplastic

Share to ATP Binding Cassette Transporter, Subfamily B

Share to ATP Binding Cassette Transporter, Subfamily B, Member 1

Share to Disease-Free Survival

Share to Doxorubicin

Share to Organic Cation Transport Proteins

Source

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Identifiers

PMID: 23116553
DOI: 10.1111/bcp.12021
PMCID: PMC3690108

Genes

ABCB1
CBR3

Variants

Provenance

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