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A functional comparison of two transplantable syngeneic mouse models of melanoma: B16F0 and YUMM1.7

2025-05-10

Abstract excerpt

The B16 murine melanoma cell lines are considered the gold standard for testing melanoma immunotherapies due to low treatment success rates. However, the clinical relevance of these models has been questioned due to a mutational landscape void of driver mutations typically seen in human melanomas and a tendency to form necrotic cores at high tumor volumes. Creating the YUMM1.7 line addressed these limitations by p...

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Literature Corpus work
c4316a76-4f1d-50fe-9459-c1a4180363c7
DOI
10.1101/2025.05.09.652938
Open publication

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A functional comparison of two transplantable syngeneic mouse models of melanoma: B16F0 and YUMM1.7DOI 10.1101/2025.05.09.652938
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