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Article

The development of a custom RNA-sequencing panel for the identification of predictive and diagnostic biomarkers in glioma.

Journal of neuro-oncology - 1 Mar 2024

Shirai Yukina, Ueno Toshihide, Kojima Shinya, Ikeuchi Hiroshi, Kitada Rina, Koyama Takafumi, Takahashi Fumiyuki, Takahashi Kazuhisa, Ichimura Koichi, Yoshida Akihiko, Sugino Hirokazu, Mano Hiroyuki, Narita Yoshitaka, Takahashi Masamichi, Kohsaka Shinji

Abstract excerpt

PURPOSE: Various molecular profiles are needed to classify malignant brain tumors, including gliomas, based on the latest classification criteria of the World Health Organization, and their poor prognosis necessitates new therapeutic targets. The Todai OncoPanel 2 RNA Panel (TOP2-RNA) is a custom-target RNA-sequencing (RNA-seq) using the junction capture method to maximize the sensitivity of detecting 455 fusion...

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Identifiers

PMID: 38363490
DOI: 10.1007/s11060-024-04563-z
PMCID: PMC10978676

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