Article
Mutant IDH1 and thrombosis in gliomas.
Acta neuropathologica - 1 Dec 2016
Unruh Dusten, Schwarze Steven R, Khoury Laith, Thomas Cheddhi, Wu Meijing, Chen Li, Chen Rui, Liu Yinxing, Schwartz Margaret A, Amidei Christina, Kumthekar Priya, Benjamin Carolina G, Song Kristine, Dawson Caleb, Rispoli Joanne M, Fatterpekar Girish, Golfinos John G, Kondziolka Douglas, Karajannis Matthias, Pacione Donato, Zagzag David, McIntyre Thomas, Snuderl Matija, Horbinski Craig
Abstract excerpt
Mutant isocitrate dehydrogenase 1 (IDH1) is common in gliomas, and produces D-2-hydroxyglutarate (D-2-HG). The full effects of IDH1 mutations on glioma biology and tumor microenvironment are unknown. We analyzed a discovery cohort of 169 World Health Organization (WHO) grade II-IV gliomas, followed by a validation cohort of 148 cases, for IDH1 mutations, intratumoral microthrombi, and venous thromboemboli (VTE)....
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