Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Identification of variants in primary and recurrent glioblastoma using a cancer-specific gene panel and whole exome sequencing.

PloS one - 1 Jan 2015

Virk Selene M, Gibson Richard M, Quinones-Mateu Miguel E, Barnholtz-Sloan Jill S

Abstract excerpt

Glioblastoma (GBM) is an aggressive, malignant brain tumor typically resulting in death of the patient within one year following diagnosis; and those who survive beyond this point usually present with tumor recurrence within two years (5-year survival is 5%). The genetic heterogeneity of GBM has made the molecular characterization of these tumors an area of great interest and has led to identification of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Brain Neoplasms
Share to Exome
Share to Glioblastoma

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Neurofibromin 1

Share to Patched-1 Receptor

Share to Patched Receptors

Share to Pilot Projects

Share to Receptors, Cell Surface

Source

Open in PubMed Open full text

Identifiers

PMID: 25950952
DOI: 10.1371/journal.pone.0124178
PMCID: PMC4423782

Genes

PTCH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification of variants in primary and recurrent glioblastoma using a cancer-specific gene panel and whole exome sequencing.PMID 25950952Read ↗

Whole exome sequencing reveals the genetic heterogeneity and evolutionary history of primary gliomas and matched recurrencesSemantic proximity Read ↗

Multi-omics analysis of primary glioblastoma cell lines shows recapitulation of pivotal molecular features of parental tumors.Semantic proximity Read ↗

Sequential filtering for clinically relevant variants as a method for clinical interpretation of whole exome sequencing findings in glioma.Semantic proximity Read ↗

Genomic landscape of glioblastoma without IDH somatic mutation in 42 cases: a comprehensive analysis using RNA sequencing data.Semantic proximity Read ↗

Comprehensive Molecular Genetic Analysis in Glioma Patients by Next Generation SequencingSemantic proximity Read ↗

Next-generation sequencing in routine brain tumor diagnostics enables an integrated diagnosis and identifies actionable targets.Semantic proximity Read ↗

An integrated genomic analysis of human glioblastoma multiforme.Semantic proximity Read ↗

Elucidating the cancer-specific genetic alteration spectrum of glioblastoma derived cell lines from whole exome and RNA sequencing.Semantic proximity Read ↗

Whole-genome and multisector exome sequencing of primary and post-treatment glioblastoma reveals patterns of tumor evolution.Semantic proximity Read ↗

Genomic analysis of primary and recurrent gliomas reveals clinical outcome related molecular featuresSemantic proximity Read ↗

Clinical utility of targeted next-generation sequencing assay in IDH-wildtype glioblastoma for therapy decision-making.Semantic proximity Read ↗

Whole Genome Sequencing-Based Discovery of Structural Variants in Glioblastoma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.