Article
An integrated genomic analysis of human glioblastoma multiforme.
Science (New York, N.Y.) - 26 Sept 2008
Parsons D Williams, Jones Siân, Zhang Xiaosong, Lin Jimmy Cheng-Ho, Leary Rebecca J, Angenendt Philipp, Mankoo Parminder, Carter Hannah, Siu I-Mei, Gallia Gary L, Olivi Alessandro, McLendon Roger, Rasheed B Ahmed, Keir Stephen, Nikolskaya Tatiana, Nikolsky Yuri, Busam Dana A, Tekleab Hanna, Diaz Luis A, Hartigan James, Smith Doug R, Strausberg Robert L, Marie Suely Kazue Nagahashi, Shinjo Sueli Mieko Oba, Yan Hai, Riggins Gregory J, Bigner Darell D, Karchin Rachel, Papadopoulos Nick, Parmigiani Giovanni, Vogelstein Bert, Velculescu Victor E, Kinzler Kenneth W
Abstract excerpt
Glioblastoma multiforme (GBM) is the most common and lethal type of brain cancer. To identify the genetic alterations in GBMs, we sequenced 20,661 protein coding genes, determined the presence of amplifications and deletions using high-density oligonucleotide arrays, and performed gene expression analyses using next-generation sequencing technologies in 22 human tumor samples. This comprehensive analysis led to...
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