Article
Actionable molecular alterations in newly diagnosed and recurrent IDH1/2 wild-type glioblastoma patients and therapeutic implications: a large mono-institutional experience using extensive next-generation sequencing analysis.
European journal of cancer (Oxford, England : 1990) - 1 Sept 2023
Padovan Marta, Maccari Marta, Bosio Alberto, De Toni Chiara, Vizzaccaro Salvatore, Cestonaro Ilaria, Corrà Martina, Caccese Mario, Cerretti Giulia, Zagonel Vittorina, Lombardi Giuseppe
Abstract excerpt
BACKGROUND: Next-generation sequencing (NGS) panels enable the identification of alterations in cancer-related genes. This may guide a molecularly targeted strategy for the treatment of glioblastoma (GBM). MATERIAL AND METHODS: We retrospectively analysed data obtained using FoundationOne®CDx in a large cohort of IDH1/2 wild-type GBM. We aimed to 1) identify potentially actionable molecular alterations at...
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