Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Humanin variant P3S is associated with longevity in APOE4 carriers and resists APOE4‐induced brain pathology

22 Mar 2024

Abstract excerpt

The APOE4 allele is recognized as a significant genetic risk factor to Alzheimer's disease (AD) and influences longevity. Nonetheless, some APOE4 carriers exhibit resistance to AD even in advanced age. Humanin, a mitochondrial-derived peptide comprising 24 amino acids, has variants linked to cognitive resilience and longevity. Our research uncovered a unique humanin variant, P3S, specifically enriched in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer's disease research and treatments
Share to GDF15 and Related Biomarkers
Share to Nuclear Receptors and Signaling

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 38520065
DOI: 10.1111/acel.14153

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Humanin variant P3S is associated with longevity in APOE4 carriers and resists APOE4‐induced brain pathologyPMID 38520065Read ↗

Humanin P3S, haplogroup N1b and the risk of Alzheimer's disease.Semantic proximity Read ↗

Alzheimer’s disease associated isoforms of human CD33 distinctively modulate microglial cell responses in 5XFAD miceSemantic proximity Read ↗

APOE4 exacerbates synapse loss and neurodegeneration in Alzheimer's disease patient iPSC-derived cerebral organoids.Semantic proximity Read ↗

In Vivo Chimeric Alzheimer’s Disease Modeling of Apolipoprotein E4 Toxicity in Human NeuronsSemantic proximity Read ↗

Alzheimer’s disease associated isoforms of human CD33 distinctively modulate microglial cell responses in 5XFAD miceSemantic proximity Read ↗

Apoe4 and Alzheimer’s Disease Pathogenesis—Mitochondrial Deregulation and Targeted Therapeutic StrategiesSemantic proximity Read ↗

APOE4 disrupts the central dogma by arresting neuronal proteome dynamicsSemantic proximity Read ↗

<i>TOMM40</i> suppression promotes neuronal cholesterol imbalance and molecular and behavioral phenotypes of Alzheimer’s diseaseSemantic proximity Read ↗

Dysregulation of neuroproteasomes by ApoE isoforms drives endogenous Tau aggregationSemantic proximity Read ↗

Alzheimer’s disease associated isoforms of human CD33 distinctively modulate microglial cell responses in 5XFAD miceSemantic proximity Read ↗

TOMM40-APOE chimera linking Alzheimer’s highest risk genes: a new pathway for mitochondria regulation and APOE4 pathogenesisSemantic proximity Read ↗

Humanized APOE genotypes influence lifespan independently of tau aggregation in the P301S mouse model of tauopathy.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.