Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Common human genetic variants of APOE impact murine COVID-19 mortality

21 Sept 2022

Abstract excerpt

Clinical outcomes of severe acute respiratory syndrome 2 (SARS-CoV-2) infection are highly heterogeneous, ranging from asymptomatic infection to lethal coronavirus disease 2019 (COVID-19). The factors underlying this heterogeneity remain insufficiently understood. Genetic association studies have suggested that genetic variants contribute to the heterogeneity of COVID-19 outcomes, but the underlying potential...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adipokines, Inflammation, and Metabolic Diseases
Share to COVID-19 Clinical Research Studies
Share to SARS-CoV-2 and COVID-19 Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 36130725
DOI: 10.1038/s41586-022-05344-2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Common human genetic variants of APOE impact murine COVID-19 mortalityPMID 36130725Read ↗

The ApoE Locus and COVID-19: Are We Going Where We Have Been?Semantic proximity Read ↗

COVID-19 enters the expanding network of apolipoprotein E4-related pathologies.Semantic proximity Read ↗

ApoE4 causes severe COVID-19 outcomes via downregulation of ACE2Semantic proximity Read ↗

ApoE4 associated with severe COVID-19 outcomes via downregulation of ACE2 and imbalanced RAS pathwaySemantic proximity Read ↗

APOE genetics influence murine gut microbiome.Semantic proximity Read ↗

The impact of APOE genotype on survival: Results of 38,537 participants from six population-based cohorts (E2-CHARGE)Semantic proximity Read ↗

The association of APOE genotype with COVID-19 disease severity.Semantic proximity Read ↗

APOE variants affect COVID-19 outcome.Semantic proximity Read ↗

A multi-discipline phenotyping platform for late-onset Alzheimer’s disease employed on a novel, humanized APOEε4.Trem2*R47H mouse modelSemantic proximity Read ↗

Common germline variants of the human APOE gene modulate melanoma progression and survival.Semantic proximity Read ↗

APOE Alleles and Diet in Brain Aging and Alzheimer’s DiseaseSemantic proximity Read ↗

APOE Genetics Influence Murine Gut MicrobiomeSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.