Article
CDKN2A/CDK4 status in Brazilian patients meeting clinical criteria for hereditary melanoma: a cross-sectional descriptive trial.
International journal of dermatology - 1 Aug 2023
Arnaut Joyce R M B, Guimarães Isabella Dos S, Dos Santos Anna Cláudia E, Rodrigues Elizângela M, Machado Jorge R da S, de Melo Andreia C
Abstract excerpt
BACKGROUND: Melanoma is the most lethal skin cancer, and its incidence has increased worldwide. About 10% of cases are classified as hereditary melanoma (HM). CDKN2A and CDK4 are the major high-risk genes. Families are also more prone to develop pancreatic cancer, and different forms of oncological surveillance are recommended. OBJECTIVES: Describe the prevalence of CDKN2A/CDK4 germline mutations in...
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