Article
[Recommendations for genetic testing and management of individuals genetically at-risk of cutaneous melanoma].
Annales de dermatologie et de venereologie - 1 Jan 2015
Avril M-F, Bahadoran P, Cabaret O, Caron O, de la Fouchardière A, Demenais F, Desjardins L, Frébourg T, Hammel P, Leccia M-T, Lesueur F, Mahé E, Martin L, Maubec E, Remenieras A, Richard S, Robert C, Soufir N, Stoppa-Lyonnet D, Thomas L, Vabres P, Bressac-de Paillerets B
Abstract excerpt
Cutaneous melanoma is a multifactorial disease resulting from both environmental and genetic factors. Five susceptibility genes have been identified over the past years, comprising high-risk susceptibility genes (CDKN2A, CDK4, and BAP1 genes) and intermediate-risk susceptibility genes (MITF, and MC1R genes). The aim of this expert consensus was to define clinical contexts justifying genetic analyses, to describe...
Topics
- Cyclin-Dependent Kinase 4
- Cyclin-Dependent Kinase Inhibitor p16
- Genetic Predisposition to Disease
- Genetic Testing
- Genotype
- Humans
- Melanoma
- Microphthalmia-Associated Transcription Factor