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Article

CDKN2A/CDK4 Status in Greek Patients with Familial Melanoma and Association with Clinico-epidemiological Parameters.

Acta dermato-venereologica - 10 Oct 2018

Karagianni Fani, Njauw Ching-Ni, Kypreou Katerina P, Stergiopoulou Aravela, Plaka Michaela, Polydorou Dorothea, Chasapi Vasiliki, Pappas Leontios, Stratigos Ioannis A, Champsas Gregory, Panagiotou Peter, Gogas Helen, Evangelou Evangelos, Tsao Hensin, Stratigos Alexander J, Stefanaki Irene

Abstract excerpt

Approximately 5-10% of melanoma cases occur in a familial context. CDKN2A/CDK4 were the first high-penetrance melanoma genes identified. The aims of this study were to evaluate CDKN2A/CDK4 variants in Greek familial melanoma patients and to correlate the mutational status with specific clinico-epidemiological characteristics. A cross-sectional study was conducted by genotyping CDKN2A/CDK4 variants and selected...

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Identifiers

PMID: 29774366
DOI: 10.2340/00015555-2969
PMCID: PMC6572781

Genes

CDK4

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