Article
Characterization of individuals at high risk of developing melanoma in Latin America: bases for genetic counseling in melanoma.
Genetics in medicine : official journal of the American College of Medical Genetics - 1 Jul 2016
Puig Susana, Potrony Miriam, Cuellar Francisco, Puig-Butille Joan Anton, Carrera Cristina, Aguilera Paula, Nagore Eduardo, Garcia-Casado Zaida, Requena Celia, Kumar Rajiv, Landman Gilles, Costa Soares de Sá Bianca, Gargantini Rezze Gisele, Facure Luciana, de Avila Alexandre Leon Ribeiro, Achatz Maria Isabel, Carraro Dirce Maria, Duprat Neto João Pedreira, Grazziotin Thais C, Bonamigo Renan R, Rey Maria Carolina W, Balestrini Claudia, Morales Enrique, Molgo Montserrat, Bakos Renato Marchiori, Ashton-Prolla Patricia, Giugliani Roberto, Larre Borges Alejandra, Barquet Virginia, Pérez Javiera, Martínez Miguel, Cabo Horacio, Cohen Sabban Emilia, Latorre Clara, Carlos-Ortega Blanca, Salas-Alanis Julio C, Gonzalez Roger, Olazaran Zulema, Malvehy Josep, Badenas Celia
Abstract excerpt
PURPOSE: CDKN2A is the main high-risk melanoma-susceptibility gene, but it has been poorly assessed in Latin America. We sought to analyze CDKN2A and MC1R in patients from Latin America with familial and sporadic multiple primary melanoma (SMP) and compare the data with those for patients from Spain to establish bases for melanoma genetic counseling in Latin America. METHODS: CDKN2A and MC1R were sequenced in 186...
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