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Germline Non-CDKN2A Variants in Melanoma and Associated Hereditary Cancer Syndromes

9 Jun 2025

Abstract excerpt

The etiology of melanoma is multifactorial and arises from the interplay of genetic, phenotypic, and environmental factors. The genetic predisposition to melanoma is influenced by a complex interaction among genes exhibiting varying levels of penetrance (high, moderate, and low), each contributing differently to the susceptibility of the disease. Furthermore, penetrance may vary based on the incidence of melanoma...

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PMID: 40558591
DOI: 10.3390/diseases13060180

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