Article
Genetic variations of patients with familial or multiple melanoma in Southern Brazil.
Journal of the European Academy of Dermatology and Venereology : JEADV - 1 Feb 2013
Grazziotin T C, Rey M C W, Bica C G, Pinto L A, Bonamigo R R, Puig-Butille J A, Cuellar F, Puig S
Abstract excerpt
BACKGROUND: Patients with familial melanoma or multiple primary melanoma represent a high-risk population to hereditary melanoma. Mutations in susceptibility genes, such as CDKN2A, CDK4 and MC1R, have been associated with the development of melanoma. OBJECTIVES: The purpose of this study was to determine the genotypic background of patients with familial and/or multiple melanoma in southern Brazil. METHODS: This...
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