Article
Characterization of cellular senescence in aging skeletal muscle.
Nature aging - 1 Jul 2022
Zhang Xu, Habiballa Leena, Aversa Zaira, Ng Yan Er, Sakamoto Ayumi E, Englund Davis A, Pearsall Vesselina M, White Thomas A, Robinson Matthew M, Rivas Donato A, Dasari Surendra, Hruby Adam J, Lagnado Anthony B, Jachim Sarah K, Granic Antoneta, Sayer Avan A, Jurk Diana, Lanza Ian R, Khosla Sundeep, Fielding Roger A, Nair K Sreekumaran, Schafer Marissa J, Passos João F, LeBrasseur Nathan K
Abstract excerpt
Senescence is a cell fate that contributes to multiple aging-related pathologies. Despite profound age-associated changes in skeletal muscle (SkM), whether its constituent cells are prone to senesce has not been methodically examined. Herein, using single cell and bulk RNA-sequencing and complementary imaging methods on SkM of young and old mice, we demonstrate that a subpopulation of old fibroadipogenic...
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