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Genome- and transcriptome-wide off-target analyses of a high-efficiency adenine base editor in tomato.

Plant physiology - 31 Aug 2023

Sretenovic Simon, Green Yumi, Wu Yuechao, Cheng Yanhao, Zhang Tao, Van Eck Joyce, Qi Yiping

Abstract excerpt

Adenine base editors (ABEs) are valuable, precise genome editing tools in plants. In recent years, the highly promising ADENINE BASE EDITOR8e (ABE8e) was reported for efficient A-to-G editing. However, compared to monocots, comprehensive off-target analyses for ABE8e are lacking in dicots. To determine the occurrence of off-target effects in tomato (Solanum lycopersicum), we assessed ABE8e and a high-fidelity...

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PMID: 37315207
DOI: 10.1093/plphys/kiad347

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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