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Article

Optimized TadA-derived base editors efficiently manipulate mRNA splicing by A-to-G and C-to-K editing in potato.

Journal of integrative plant biology - 1 Sept 2026

Chen Kaiyuan, Zhang Yan, Deng Jiuzhou, Zhang Lumin, Zhou Huiying, Duan Yaxin, Xiao Enle, Zhu Guangtao, Zhang Chunzhi

Abstract excerpt

Pre-messenger RNA (pre-mRNA) splicing is a critical mechanism for post-transcriptional regulation in plants. Through alternative splicing, plants produce diverse transcriptomes and proteomes that finely regulate development as well as responses to biotic and abiotic stresses. However, modulating the generation of specific splicing isoforms for functional characterization remains challenging, particularly in the...

Read the complete abstract on PubMed

Topics

Solanum tuberosum
RNA Splicing
RNA, Messenger
Plants, Genetically Modified
RNA Editing
Base Sequence

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Mutation

Alternative Splicing

Source

Open in PubMed Open full text

Identifiers

PMID: 42010791
DOI: 10.1111/jipb.70263
PMCID: PMC13545826

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

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