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Article

Parkinson's disease in a patient with GBA and LRRK2 covariants after acute hypoxic insult: a case report.

BMC neurology - 10 Jun 2023

Tang Yuting, Wei Lijian, Wu Zhuohua, Xu Pingyi, Mo Mingshu

Abstract excerpt

BACKGROUND: The glucocerebrosidase (GBA) and leucine-rich repeat kinase 2 (LRRK2) genes are associated with the risk of sporadic Parkinson's disease (PD). As an environmental factor, hypoxic insults may impair dopamine neurons in the substantia nigra and exacerbate PD symptoms. However, covariants of GBA and LRRK2 combined with hypoxic insults in clinical cases of Parkinsonism have not yet been reported. CASE...

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Identifiers

PMID: 37301871
DOI: 10.1186/s12883-023-03269-5
PMCID: PMC10257258

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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