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Article

A Possible Modifying Effect of the G2019S Mutation in the LRRK2 Gene on GBA Parkinson's Disease.

Movement disorders : official journal of the Movement Disorder Society - 1 Jul 2020

Omer Nurit, Giladi Nir, Gurevich Tanya, Bar-Shira Anat, Gana-Weisz Mali, Goldstein Orly, Kestenbaum Meir, Cedarbaum Jesse M, Orr-Urtreger Avi, Mirelman Anat, Thaler Avner

Abstract excerpt

BACKGROUND: The phenotype of Parkinson's disease (PD) is milder among patients with LRRK2-PD and more severe among patients with GBA-PD; however, whether an additive phenotypical effect occurs among dual-mutation carriers requires validation. OBJECTIVE: The objective of this study was to explore the phenotypic expression of patients with PD who carry mutations in both genes compared with a single-mutation...

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PMID: 32353202
DOI: 10.1002/mds.28066

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