Genetic and Environmental Factors Influence the Pleomorphy of LRRK2 Parkinsonism.

Abstract excerpt

Missense mutations in the LRRK2 gene were first identified as a pathogenic cause of Parkinson's disease (PD) in 2004. Soon thereafter, a founder mutation in LRRK2, p.G2019S (rs34637584), was described, and it is now estimated that there are approximately 100,000 people worldwide carrying this risk variant. While the clinical presentation of LRRK2 parkinsonism has been largely indistinguishable from sporadic PD,...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Disease Susceptibility