Article
A village in a dish model system for population-scale hiPSC studies.
Nature communications - 9 Jun 2023
Neavin Drew R, Steinmann Angela M, Farbehi Nona, Chiu Han Sheng, Daniszewski Maciej S, Arora Himanshi, Bermudez Yasmin, Moutinho Cátia, Chan Chia-Ling, Bax Monique, Tyebally Mubarika, Gnanasambandapillai Vikkitharan, Lam Chuan E, Nguyen Uyen, Hernández Damián, Lidgerwood Grace E, Graham Robert M, Hewitt Alex W, Pébay Alice, Palpant Nathan J, Powell Joseph E
Abstract excerpt
The mechanisms by which DNA alleles contribute to disease risk, drug response, and other human phenotypes are highly context-specific, varying across cell types and different conditions. Human induced pluripotent stem cells are uniquely suited to study these context-dependent effects but cell lines from hundreds or thousands of individuals are required. Village cultures, where multiple induced pluripotent stem...
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