Cell villages and Dirichlet modeling map human cell fitness genetics

Abstract excerpt

The capacity of cells to proliferate and survive is central to development and disease. Assays that measure cell fitness are therefore a cornerstone of biology, but traditional techniques lack donor diversity and have high technical variability that impedes scale and reproducibility. To overcome these barriers, we designed and validated a “cell village”-based fitness screening approach using pooled cultures of 12–...

Topics

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• Cell Differentiation
• Cell Line
• Cells
• Genetic Variation
• Induced Pluripotent Stem Cells
• Machine Learning
• Models, Biological
• Phenotype

Identifiers and source

Literature Corpus work

ac8899ba-a35c-5d33-a9ec-ea403b23d7f8

DOI

10.1101/2025.09.26.678880