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Article

Investigating the novel-binding site of RPA2 on Menin and predicting the effect of point mutation of Menin through protein-protein interactions.

Scientific reports - 8 Jun 2023

Kaur Gurjeet, Prajapat Manisha, Singh Harvinder, Sarma Phulen, Bhadada Sanjay Kumar, Shekhar Nishant, Sharma Saurabh, Sinha Shweta, Kumar Subodh, Prakash Ajay, Medhi Bikash

Abstract excerpt

Protein-protein interactions (PPIs) play a critical role in all biological processes. Menin is tumor suppressor protein, mutated in multiple endocrine neoplasia type 1 syndrome and has been shown to interact with multiple transcription factors including (RPA2) subunit of replication protein A (RPA). RPA2, heterotrimeric protein required for DNA repair, recombination and replication. However, it's still remains...

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Identifiers

PMID: 37291166
DOI: 10.1038/s41598-023-35599-2
PMCID: PMC10250348

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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