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Investigating the Effects of Amino Acid Variations in Human Menin.

Molecules (Basel, Switzerland) - 7 Mar 2022

Biancaniello Carmen, D'Argenio Antonia, Giordano Deborah, Dotolo Serena, Scafuri Bernardina, Marabotti Anna, d'Acierno Antonio, Tagliaferri Roberto, Facchiano Angelo

Abstract excerpt

Human menin is a nuclear protein that participates in many cellular processes, as transcriptional regulation, DNA damage repair, cell signaling, cell division, proliferation, and migration, by interacting with many other proteins. Mutations of the gene encoding menin cause multiple endocrine neoplasia type 1 (MEN1), a rare autosomal dominant disorder associated with tumors of the endocrine glands. In order to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35268848
DOI: 10.3390/molecules27051747
PMCID: PMC8911756

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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