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Article

Theoretical prediction of the binding free energy for mutants of replication protein A.

Journal of molecular modeling - 1 Jul 2012

Carra Claudio, Saha Janapriya, Cucinotta Francis A

Abstract excerpt

The replication protein A (RPA) is a heterotrimeric (70, 32, and 14 kDa subunits), single stranded DNA (ssDNA) binding protein required for pivotal functions in the cell metabolism, such as chromosomal replication, prevention of hairpin formation, DNA repair and recombination, and signaling after DNA damage. Studies based on deletions and mutations have identified the high affinity ssDNA binding domains in the 70...

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PMID: 22160652
DOI: 10.1007/s00894-011-1313-z

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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