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Elucidating the Mutational Landscape in Hepatocyte Nuclear Factor 1β (HNF1B) by Computational Approach.

Advances in protein chemistry and structural biology - 1 Jan 2000

Sneha P, Doss C G P

Abstract excerpt

Transcription factors are the major gene-regulatory proteins that recognize specific nucleotide sequences and bind to them. Missense mutations in transcription factors play a significant role in misregulation of gene expression contributing to various diseases and disorders. Understanding their structural and functional impact of the disease-causing mutations becomes prime importance in treating a disease....

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PMID: 28215227
DOI: 10.1016/bs.apcsb.2016.11.005

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