Mapping increased flexibility and conformational divergence via N-terminal helix-to-coil transition in USP12 mutant Y49N: a comprehensive in-detail normal mode simulation study.

Abstract excerpt

The family of deubiquitinating enzymes is primarily involved in the removal of ubiquitin chains from specific target proteins. Among these proteins, ubiquitin-specific protease 12 (USP12 protein) has been identified as a key molecule in regulating cellular homeostasis, cancer progression, and immune regulation. This protein is reportedly associated with colorectal cancer, prostate cancer, and breast cancer, along...

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• Amino Acid Sequence
• Models, Molecular
• Molecular Dynamics Simulation
• Mutant Proteins
• Mutation