Article
Correlation between KRAS and NRAS mutational status and clinicopathological features in 414 cases of metastatic colorectal cancer in Morocco: the largest North African case series.
BMC gastroenterology - 5 Jun 2023
Mahdi Youssef, Khmou Mouna, Souadka Amine, Agouri Hajar El, Ech-Charif Soumaya, Mounjid Chaimaa, Khannoussi Basma El
Abstract excerpt
BACKGROUND: Advances in molecular biology have improved understanding of the molecular features of carcinogenesis and progression of colorectal cancer. It is clear that the efficacy of anti-EGFR depends upon the RAS mutational status, since any mutation in RAS is associated with resistance to anti-EGFR therapy. The aim of this study is to report the largest North African description of KRAS and NRAS status in...
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