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Tumor profiling of KRAS, BRAF, and NRAS gene mutations in patients with colorectal cancer: A Lebanese major center cohort study.

Gene - 5 Aug 2022

Baba Omar, Bidikian Aram, Mukherji Deborah, Shamseddin Ali, Temraz Sally, Fakhruddin Najla, Khazzouh Mira, Ghizzawi Diana, Abdel Khalek Rabab, Zaatari Ghazi, Mahfouz Rami

Abstract excerpt

BACKGROUND: In the era of precision medicine, treatment schemes for advanced Colorectal (CRC) disease include monoclonal antibodies which block the epidermal growth factor receptor (EGFR) implicated in tumor proliferation, invasion, migration and neovascularization. Resistance to these agents has been correlated with activating downstream mutations in KRAS, BRAF and NRAS genes, among others, leading to...

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PMID: 35680020
DOI: 10.1016/j.gene.2022.146646

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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