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Genome-Wide Association Meta-Analysis Supports Genes Involved in Valve and Cardiac Development to Associate With Mitral Valve Prolapse.

Circulation. Genomic and precision medicine - 1 Oct 2021

Yu Mengyao, Kyryachenko Sergiy, Debette Stephanie, Amouyel Philippe, Schott Jean-Jacques, Le Tourneau Thierry, Dina Christian, Norris Russell A, Hagège Albert A, Jeunemaitre Xavier, Bouatia-Naji Nabila

Abstract excerpt

BACKGROUND: Mitral valve prolapse (MVP) is a common cardiac valve disease, which affects 1 in 40 in the general population. Previous genome-wide association study has identified 6 risk loci for MVP. But these loci explained only partially the genetic risk for MVP. We aim to identify additional risk loci for MVP by adding data set from the UK Biobank. METHODS: We also incorporated 434 MVP cases and 4527 controls...

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Identifiers

PMID: 34461747
DOI: 10.1161/CIRCGEN.120.003148
PMCID: PMC8530910

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