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Article

Reduced YAP1 and FOLR1 in gliomas predict better response to chemotherapeutics.

Cellular signalling - 1 Sept 2023

Patrick Shruti, Lathoria Kirti, Suri Vaishali, Sen Ellora

Abstract excerpt

Gliomas harbouring mutations in IDH1 (isocitrate dehydrogenase 1) are characterized by greater sensitivity to chemotherapeutics. These mutants also exhibit diminished levels of transcriptional coactivator YAP1 (yes-associated protein 1). Enhanced DNA damage in IDH1 mutant cells, as evidenced by γH2AX formation (phosphorylation of histone variant H2A.X) and ATM (serine/threonine kinase; ataxia telangiectasia...

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Identifiers

PMID: 37269960
DOI: 10.1016/j.cellsig.2023.110738

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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