Article

XRRA1 acts as a molecular brake on radiation-induced DNA damage signaling and immunogenic cell death in tumor cells

2026-04-24

Abstract excerpt

Radiotherapy kills cancer cells by inducing DNA damage, but adaptive responses that buffer injury and limit immunogenic signaling remain incompletely understood. Although ionizing radiation can activate cytosolic DNA sensing and immunogenic cell death, the tumor-intrinsic regulators linking these processes to radioresistance are not well defined. Here, we show that XRRA1 is a stress-adaptive determinant of radiore...

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Identifiers and source

Literature Corpus work: 797747f0-adc7-5204-8783-760aacf30247
DOI: 10.64898/2026.04.21.719372

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