RNF7-Mediated ROS Targets Malignant Phenotype and Radiotherapy Sensitivity in Glioma With Different IDH1 Genotypes.

doi:10.1002/mc.23876

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Article

RNF7-Mediated ROS Targets Malignant Phenotype and Radiotherapy Sensitivity in Glioma With Different IDH1 Genotypes.

Molecular carcinogenesis - 1 Apr 2025

Tao Yiran, Shi Zimin, Liang Xianyin, Zheng Yuqian, Dai Lirui, Li Xiang, Li Zian, Liang Wulong, Bai Gaojie, Li Hao, Lyu Yuan, Li Junqi, Zhang Tao, Hu Weihua, Zhou Shaolong, Shan Qiao, Fu Xudong, Wang Xinjun

Abstract excerpt

RNF7 (Ring Finger Protein 7) is a key component of CRLs (Cullin-RING-type E3 ubiquitin ligases) and has been found to possess intrinsic anti-ROS capabilities. Aberrant expression of RNF7 has been observed in various tumor types and is known to significantly influence tumor initiation and progression. However, the specific role of RNF7 in glioblastoma remains unclear. IDH (isocitrate dehydrogenase) mutations,...

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Topics

Humans
Isocitrate Dehydrogenase
Glioma
Reactive Oxygen Species
Radiation Tolerance

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Ubiquitin-Protein Ligases

Brain Neoplasms

Mutation

Prognosis

Cell Line, Tumor

Gene Expression Regulation, Neoplastic

Genotype

Phenotype

Oxidative Stress

Biomarkers, Tumor

Source

Open in PubMed Open full text

Identifiers

PMID: 39783768
DOI: 10.1002/mc.23876
PMCID: PMC11890431

Genes

RNF7
IDH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

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