Article
Frequent ATRX, CIC, FUBP1 and IDH1 mutations refine the classification of malignant gliomas.
Oncotarget - 1 Jul 2012
Jiao Yuchen, Killela Patrick J, Reitman Zachary J, Rasheed Ahmed B, Heaphy Christopher M, de Wilde Roeland F, Rodriguez Fausto J, Rosemberg Sergio, Oba-Shinjo Sueli Mieko, Nagahashi Marie Suely Kazue, Bettegowda Chetan, Agrawal Nishant, Lipp Eric, Pirozzi Christopher, Lopez Giselle, He Yiping, Friedman Henry, Friedman Allan H, Riggins Gregory J, Holdhoff Matthias, Burger Peter, McLendon Roger, Bigner Darell D, Vogelstein Bert, Meeker Alan K, Kinzler Kenneth W, Papadopoulos Nickolas, Diaz Luis A, Yan Hai
Abstract excerpt
Mutations in the critical chromatin modifier ATRX and mutations in CIC and FUBP1, which are potent regulators of cell growth, have been discovered in specific subtypes of gliomas, the most common type of primary malignant brain tumors. However, the frequency of these mutations in many subtypes of gliomas, and their association with clinical features of the patients, is poorly understood. Here we analyzed these...
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