Article

Resurrection of endogenous retroviruses during aging reinforces senescence

2021-02-22

Abstract excerpt

<h4>SUMMARY</h4> Whether and how certain transposable elements with viral origins, such as endogenous retroviruses (ERVs) dormant in our genomes, can become awakened and contribute to the aging process are largely unknown. In human senescent cells, we found that HERVK (HML-2), the most recently integrated human ERVs, are unlocked to transcribe viral genes and produce retrovirus-like particles (RVLPs). These HERVK...

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Literature Corpus work: e22a7252-34ed-50e3-be89-070a937ea5c3
DOI: 10.1101/2021.02.22.432260

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