Genome-Wide Association of CKD Progression: The Chronic Renal Insufficiency Cohort Study.

doi:10.1681/ASN.2015101152

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Article

Genome-Wide Association of CKD Progression: The Chronic Renal Insufficiency Cohort Study.

Journal of the American Society of Nephrology : JASN - 1 Mar 2017

Parsa Afshin, Kanetsky Peter A, Xiao Rui, Gupta Jayanta, Mitra Nandita, Limou Sophie, Xie Dawei, Xu Huichun, Anderson Amanda Hyre, Ojo Akinlolu, Kusek John W, Lora Claudia M, Hamm L Lee, He Jiang, Sandholm Niina, Jeff Janina, Raj Dominic E, Böger Carsten A, Bottinger Erwin, Salimi Shabnam, Parekh Rulan S, Adler Sharon G, Langefeld Carl D, Bowden Donald W, Groop Per-Henrik, Forsblom Carol, Freedman Barry I, Lipkowitz Michael, Fox Caroline S, Winkler Cheryl A, Feldman Harold I

Abstract excerpt

The rate of decline of renal function varies significantly among individuals with CKD. To understand better the contribution of genetics to CKD progression, we performed a genome-wide association study among participants in the Chronic Renal Insufficiency Cohort Study. Our outcome of interest was CKD progression measured as change in eGFR over time among 1331 blacks and 1476 whites with CKD. We stratified all...

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PMID: 27729571
DOI: 10.1681/ASN.2015101152
PMCID: PMC5328149

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