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Article

Melatonin receptor 1A (MTNR1A) gene linkage and association to type 2 diabetes in Italian families.

European review for medical and pharmacological sciences - 1 May 2023

Amin M, Gragnoli C

Abstract excerpt

OBJECTIVE: Melatonin regulates the mammalian circadian rhythm and plays metabolic functions such as glucose homeostasis. Both melatonin receptors (MTNR1A and MTNR1B, encoded by the MTNR1A and MTNR1B genes, respectively) are expressed in pancreatic beta cells and mediate the glucometabolic roles of melatonin as well as insulin secretion. The MTNR1B gene is a well-known genetic risk factor in type 2 diabetes (T2D);...

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PMID: 37259752
DOI: 10.26355/eurrev_202305_32480

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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