Article
A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk.
Nature genetics - 1 Jan 2009
Bouatia-Naji Nabila, Bonnefond Amélie, Cavalcanti-Proença Christine, Sparsø Thomas, Holmkvist Johan, Marchand Marion, Delplanque Jérôme, Lobbens Stéphane, Rocheleau Ghislain, Durand Emmanuelle, De Graeve Franck, Chèvre Jean-Claude, Borch-Johnsen Knut, Hartikainen Anna-Liisa, Ruokonen Aimo, Tichet Jean, Marre Michel, Weill Jacques, Heude Barbara, Tauber Maithé, Lemaire Katleen, Schuit Frans, Elliott Paul, Jørgensen Torben, Charpentier Guillaume, Hadjadj Samy, Cauchi Stéphane, Vaxillaire Martine, Sladek Robert, Visvikis-Siest Sophie, Balkau Beverley, Lévy-Marchal Claire, Pattou François, Meyre David, Blakemore Alexandra I F, Jarvelin Marjo-Riita, Walley Andrew J, Hansen Torben, Dina Christian, Pedersen Oluf, Froguel Philippe
Abstract excerpt
In genome-wide association (GWA) data from 2,151 nondiabetic French subjects, we identified rs1387153, near MTNR1B (which encodes the melatonin receptor 2 (MT2)), as a modulator of fasting plasma glucose (FPG; P = 1.3 x 10(-7)). In European populations, the rs1387153 T allele is associated with increased FPG (beta = 0.06 mmol/l, P = 7.6 x 10(-29), N = 16,094), type 2 diabetes (T2D) risk (odds ratio (OR) = 1.15,...
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