Article
Whole-exome sequencing identifies common and rare variant metabolic QTLs in a Middle Eastern population.
Nature communications - 23 Jan 2018
Yousri Noha A, Fakhro Khalid A, Robay Amal, Rodriguez-Flores Juan L, Mohney Robert P, Zeriri Hassina, Odeh Tala, Kader Sara Abdul, Aldous Eman K, Thareja Gaurav, Kumar Manish, Al-Shakaki Alya, Chidiac Omar M, Mohamoud Yasmin A, Mezey Jason G, Malek Joel A, Crystal Ronald G, Suhre Karsten
Abstract excerpt
Metabolomics-genome-wide association studies (mGWAS) have uncovered many metabolic quantitative trait loci (mQTLs) influencing human metabolic individuality, though predominantly in European cohorts. By combining whole-exome sequencing with a high-resolution metabolomics profiling for a highly consanguineous Middle Eastern population, we discover 21 common variant and 12 functional rare variant mQTLs, of which...
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