A tripartite complex of suPAR, APOL1 risk variants and αvβ3 integrin on podocytes mediates chronic kidney disease.

doi:10.1038/nm.4362

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Article

A tripartite complex of suPAR, APOL1 risk variants and αvβ3 integrin on podocytes mediates chronic kidney disease.

Nature medicine - 1 Aug 2017

Hayek Salim S, Koh Kwi Hye, Grams Morgan E, Wei Changli, Ko Yi-An, Li Jing, Samelko Beata, Lee Hyun, Dande Ranadheer R, Lee Ha Won, Hahm Eunsil, Peev Vasil, Tracy Melissa, Tardi Nicholas J, Gupta Vineet, Altintas Mehmet M, Garborcauskas Garrett, Stojanovic Nikolina, Winkler Cheryl A, Lipkowitz Michael S, Tin Adrienne, Inker Lesley A, Levey Andrew S, Zeier Martin, Freedman Barry I, Kopp Jeffrey B, Skorecki Karl, Coresh Josef, Quyyumi Arshed A, Sever Sanja, Reiser Jochen

Abstract excerpt

Soluble urokinase plasminogen activator receptor (suPAR) independently predicts chronic kidney disease (CKD) incidence and progression. Apolipoprotein L1 (APOL1) gene variants G1 and G2, but not the reference allele (G0), are associated with an increased risk of CKD in individuals of recent African ancestry. Here we show in two large, unrelated cohorts that decline in kidney function associated with APOL1 risk...

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Identifiers

PMID: 28650456
DOI: 10.1038/nm.4362
PMCID: PMC6019326

Genes

APOL1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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