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Deubiquitinase USP1 influences the dedifferentiation of mouse pancreatic β-cells

26 Apr 2023

Abstract excerpt

Loss of insulin-secreting β-cells in diabetes may be either due to apoptosis or dedifferentiation of β-cell mass. The ubiquitin-proteasome system comprising E3 ligase and deubiquitinases (DUBs) controls several aspects of β-cell functions. In this study, screening for key DUBs identified USP1 to be specifically involved in dedifferentiation process. Inhibition of USP1 either by genetic intervention or...

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PMID: 37250303
DOI: 10.1016/j.isci.2023.106771

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