Article

Deubiquitinase USP1 influences the dedifferentiation of mouse pancreatic β-cells

2022-10-14

Abstract excerpt

Diabetes is a metabolic disease caused majorly due to loss of insulin secreting β-cells. Along with apoptosis, recent reports revealed dedifferentiation to be the added reason for the reduced β-cell mass. The Ubiquitin Proteasome system comprising of E3 ligase and deubiquitinases (DUBs) control several key aspects of pancreatic β-cell functions. The role of deubiquitinases in orchestrating the dedifferentiation pr...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 138e7468-05a2-5057-91b6-6c35ab97fb3f
DOI: 10.1101/2022.10.14.512247

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Deubiquitinase USP1 influences the dedifferentiation of mouse pancreatic β-cellsDOI 10.1101/2022.10.14.512247Read

Deubiquitinase USP1 influences the dedifferentiation of mouse pancreatic β-cellsSemantic proximity Read

Loss of Deubiquitinase USP1 Blocks Pancreatic β-Cell Apoptosis by Inhibiting DNA Damage ResponseSemantic proximity Read

PDX1 is the cornerstone of pancreatic β-cell functions and identitySemantic proximity Read

RNA-Seq Analysis of Islets to Characterise the Dedifferentiation in Type 2 Diabetes Model Mice db/dbSemantic proximity Read

Targeting β-cell dedifferentiation and transdifferentiation: opportunities and challengesSemantic proximity Read

Deubiquitinase USP18 promotes the progression of pancreatic cancer via enhancing the Notch1-c-Myc axisSemantic proximity Read

Loss of Prohibitin Induces Mitochondrial Damages Altering β-Cell Function and Survival and Is Responsible for Gradual Diabetes DevelopmentSemantic proximity Read

The miR-200–Zeb1 axis regulates key aspects of β-cell function and survival in vivoSemantic proximity Read

Pancreatic duodenal homeobox-1, PDX-1, a major regulator of beta cell identity and function.Semantic proximity Read

Deubiquitinase USP1 enhances CCAAT/enhancer-binding protein beta (C/EBPβ) stability and accelerates adipogenesis and lipid accumulationSemantic proximity Read

Incomplete Re‐Expression of Neuroendocrine Progenitor/Stem Cell Markers is a Key Feature of β‐Cell DedifferentiationSemantic proximity Read

USP33 promotes pancreatic cancer malignant phenotype through the regulation of TGFBR2/TGFβ signaling pathway.Semantic proximity Read