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Article

Pancreatic duodenal homeobox-1, PDX-1, a major regulator of beta cell identity and function.

Diabetologia - 1 Oct 2001

McKinnon C M, Docherty K

Abstract excerpt

Pancreatic duodenal homeobox -1 is a transcription factor that is expressed in beta and delta cells of the islets of Langerhans and in dispersed endocrine cells of the duodenum. It is involved in regulating the expression of a number of key beta-cell genes as well as somatostatin. It also plays a pivotal part in the development of the pancreas and islet cell ontogeny. Thus homozygous disruption of the gene in...

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Identifiers

PMID: 11692168
DOI: 10.1007/s001250100628

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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